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"We are proud of Incyte's scientists and development teams that have made this milestone possible, and we're pleased that eligible vitiligo patients now have a choice to address repigmentation." The discoloration doesn't usually cause a medical risk but can result in physical complications, such as eye issues, hearing problems and severe sunburn

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Mechanistically, Epitalons effect appears to involve a direct interaction with promoter regions of the telomerase gene, where it binds specific DNA sequences (such as ATTTC motifs), potentially modulating transcriptional activity

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doi: 10.1016/j.neuint.2017.05.019 23 MaaloufMSullivanPGDavisLKimDYRhoJM