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Metabolic intermediates including -ketoglutarate and acetyl-CoA fulfill biosynthetic demands for nucleotide/lipid production while enabling epigenetic reprogramming via TET (Ten-eleven translocation enzymes) dioxygenase-mediated DNA demethylation (108, 109)

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Half-life & zero-order kinetics : Phenytoins metabolism is saturable , resulting in zero-order kinetics (a fixed amount of the drug is cleared regardless of the drug level)