Sadoshima, J., Xu, Y., Slayter, H
This ECS vulnerability may help explain why some people are pushed toward psychosis or schizophrenia with cannabis use, especially high-THC exposure
[17] [18] [19] o -phenanthroline: heterocyclic organic compound, known to inhibit zinc-metalloenzymes [20] EDTA: molecule that chelates Zn 2+ ions and effectively inactivates PLC, known to inhibit zinc-metalloenzymes [21] Biological function [edit] PLC cleaves the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP 2 ) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP 3 )
doi:10.5334/jcr.190
This process is accompanied by the ETC breakdown with the failure to produce the necessary amount of ATP, uncompensated production of ROS and RNS, and breakdown of various molecules, which leads to the loss of mitochondrial and cell integrity, and activation of programmed cell death and necrosis
Schlachetzki JCM: chronic peripheral inflammation: a possible contributor to neurodegenerative diseases
