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This myth propagated in the 2000s, based on the factual information that eating and digesting food burns caloriesprotein in particular has a high thermic effect. Hence, if you ate 100 grams of protein in 10-gram increments, rather than two 50-gram doses, youd theoretically kindle the metabolic flame more often

The eating patterns you develop during this phase should be ones you can maintain indefinitely, not just while on the medication

SURMOUNT-1 (Jastreboff et al., NEJM 2022) reported 22.5% body weight loss at 72 weeks at the 15 mg dose

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June 5, 2025