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The normalization of intestinal permeability, while not formally included among STRIDE-II targets, represents a desirable future endpoint that may further refine the assessment of barrier restoration

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Eli Lilly and Company, the developer of retatrutide, noted that both the 9 mg and 12 mg doses of retatrutide consistently outperformed placebo across all main efficacy measures

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We dont know the cause yet, and in both trials, it apparently led to a few patients stopping the drug

The research tells a different story