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Aside from weight gain, the menopause transition is associated with changes in body composition including an increase in fat mass, a decrease in lean mass, and an increase in abdominal adiposity, say researchers

PIONEER 9 and 10 only included patients from Japan that had a lower average body weight, were mostly male (68% to 83% of patients) and were on a combination of background therapies that is atypical for patients living in Canada (high use of TZD and Alpha-glucosidase inhibitor in PIONEER 10)

Smatov, S., Mukasheva, F., & Erisken, C

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