First reaction: Holo-AASS converts lysine to saccharopine, using NADPH, a proton (H + ), and -ketoglutarate, releasing H 2 O and NADP +
It may also impact how glucose gets used
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Supports antioxidant defense and cellular energy
CCO is the terminal enzyme in the mitochondrial electron transport chain (ETC) ( During PBM for KOA, this molecular cascade activates CCO in synovial macrophages, releasing NO that collectively restarts mitochondrial respiration and initiates downstream signalling networks ( Figures 1 , 2 )