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Characterised by Francis and colleagues in the Journal of Molecular Endocrinology in 1992

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Interestingly, the expression of IGF-I and IGF-IR is profoundly reduced in the growth plates of the Cart CaSR / mice (44), suggesting that Ca 2+ /CaSR promotes chondrocyte differentiation, at least in part, by enhancing IGF-I signaling (Figure 1)

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Mitochondrial antioxidant found to drive breast cancer metastasis Key takeaways While antioxidants generally promote health, researchers have learned that under certain conditions some antioxidants operating within cellular compartments can fuel the spread of cancer