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The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable

Why It Matters: Irregular timing creates fluctuating plasma levels, preventing stable NNMT inhibition and reducing overall effectiveness

For certain patient populations, overeating is not the primary driver of excess adiposity

There is a variety of vitamin B12 supplements available

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