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6.10.4 Therapeutic strategies 6.10.4.1 Small molecules One study has proven that a potent ALK5 inhibitor, namely SB431542, can inhibit related molecules, such as TGF-, Smad3, Smad2, and a-SMA, and upregulates anti-fibrotic factor MMP2 in rats with DHEA-induced PCOS, thereby mitigating ovarian fibrosis via the TGF-/Smads signaling pathway (283)

These strategies may include dietary modifications, exercise routines, and other healthy lifestyle changes

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