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The compound was developed in the late 1990s by Novo Nordisk and characterised in a 1998 paper as the first selective GH secretagogue, meaning it stimulated GH release without the prolactin, ACTH, cortisol, or aldosterone elevations seen with earlier GHRPs

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Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2

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doi: 10.1016/S1474-4422(13)70210-2 289 Vande VeldeC.McDonaldK