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There is real science suggesting biological activity, but the clinical evidence is weak and conflicting

What the Studies Say About Firmer Skin This all sounds great, but what do the numbers show

3.2.4 Ferroptosis and amyotrophic lateral sclerosis ALS is a lethal NDD characterized by progressive degeneration of upper and lower motor neurons in the cerebral cortex, brainstem, and spinal cord, leading to skeletal muscle atrophy, weakness, weight loss, dysarthria, dysphagia, paralysis, and ultimately death from respiratory failure (Urano et al., 2025)

Fennell, L

Which is more than I expected

Strat-M makes it possible to predict the diffusion processes in human skin for various compounds and formulations, including CACs [60]