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Now it seems oral small-molecule GLP-1s also dial back eating for pleasure by engaging a brain reward circuit. Lorenzo Leggio, clinical director of NIHs National Institute on Drug Abuse, noted the importance of understanding the neural mechanisms as patient uptake increases

Wegovy is a relatively expensive medication

Garcia-Prez 2013)

Cardiovascular outcomes GLP-1 receptor agonists have demonstrated cardiovascular risk reduction in large outcome trials

In addition, fatigue and brain fog side effects sometimes reported with GLP-1s may be worsened in people with untreated thyroid dysfunction, making it harder to tolerate treatment

Pandemic of Testosterone Abuse: Considerations for Male Fertility