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GLP-1 promotes the disassembly of F-actin, improving cell glucose sensitivity and insulin secretion following sustained glucotoxicity 7

Analogously, FTO degraders have been disclosed, including a proof-of-concept PROTAC and a ligand-induced degradation mechanism using vitamin E succinate via the DTX2/UFD1 pathwaytogether suggesting multiple routes to extinguish FTO function beyond occupancy

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