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Some healed plaques do not cause any clinical events, but others undergo structural changes over a period of days to weeks that eventually occlude the vessel, resulting in an acute ischemic event (eg, a heart attack) long after the initial plaque destabilization

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doi:10.1186/gb-2002-3-5-research0025

Brogi S et al (2014) Disease-modifying anti-Alzheimers drugs: inhibitors of human cholinesterases interfering with beta-amyloid aggregation