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The mean age was 59.25 years (range, 30-80 years).The indications for treatment were actinic keratosis (7 patients, 35%), basal cell carcinoma (6 patients, 30%), actinic keratosis and basal cell carcinoma (3 patients, 15%), necrobiosis lipoidica (1 patient, 5%), porokeratosis (1 patient, 5%), and segmental Darier disease (1 patient, 5%)

However, another study using the CLP mouse model found that administering choline before and after sepsis initiation reduced serum inflammatory mediators such as TNF- and HMGB1, and improved survival via the 7nAChR-dependent mechanism (250, 251)

Taking high concentrations of melatonin or consuming unknown ingredients could lead to unexpected side effects, and being pregnant can make you more sensitive or vulnerable to side effects (Erland, 2017)