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Finally, although neuroimaging and behavioural studies provide important mechanistic clues, they generally do not establish causal relationships between GLP-1RA exposure, central reward-circuit modulation, altered liking or wanting, and long-term eating behaviour in humans

In patients with T2DM, extended treatment with insulin can significantly improve endothelial-dependent vasodilation (113)

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Despite promising results, these methods have remained experimental and are targeted toward patients already experiencing xerostomia

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