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In rat studies, BPC-157 applied immediately after sciatic nerve injury significantly improved the healing process, accelerating axonal regeneration, increasing motor action potentials, and improving functional recovery

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254,255 High-fat diet-fed mice treated with exendin-4 (a hormone found in the saliva of the Gila monster which is synthetically modified to produce exenatide for T2D treatment) had decreased mRNA levels of the pro-inflammatory cytokines tumour necrosis factor-alpha, monocyte chemoattractant protein 1 and signal transducer and activator of transcription 3

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1 and 2), thereby improving protein adsorption and subsequent biological interactions at the implanttissue interface [3, 8,9,10,11,12,13]

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