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The announcement to expand into Canada doesn't come as a surprise, but it does "reinforce the companys ability to leverage generically-available products in new markets, diversify its revenue base, and extend its care model globally," Michael Cherny, Senior Research Analyst at Leerink Partners, said in a research note

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The rationale was to simultaneously inhibit HIF-1 signaling and VEGF-mediated angiogenesis, two key pathways driving tumor growth under hypoxic conditions

Specifically, recent studies in a model of ischemia/reperfusion injury in mice demonstrated that GRP78 activity was suppressed by the overexpression of p62, a macroautophagy driver (Quan et al., 2025)

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