how to poop while taking semaglutide Better if You're on a GLP-1 Medication Does GLP-1 Make You Poop

Roughly three out of four patients experience some form of nausea during the first four weeks, but most patients say the discomfort is tolerable

Mounjaro and Zepbound contain tirzepatide, which targets two hormones instead of one, potentially producing stronger appetite suppression and greater weight loss for people who have plateaued on semaglutide alone

Additionally, drugs that affect digestion or slow gastric emptying may influence how semaglutide works

Sources: STEP 1 Trial, Wegovy prescribing information, Novo Nordisk

Again, there is minimal research on microdosing, but proponents tout a few potential perks: Milder side effects: Ozempic, Zepbound, and other similar medications can cause gnarly gut issues (nausea, vomiting, diarrhea)

Recent studies from 2025 have shown that tirzepatide demonstrates superior weight loss results compared to semaglutide in head-to-head comparisons