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Hypothalamic-pituitary-adrenal (HPA) axis and cortisol dysregulation The dysregulation of the HPA axis is a significant pathway linking depression with T2DM [70]

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miR-21 also contributes to Th17 differentiation by inhibiting the caspase pathway [52], promoting RORt expression, and enhancing TGF-/Smad signaling [53, 54]

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