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NICE advises continuing treatment only if there is a clinically meaningful HbA1c reduction (for example 11 mmol/mol [1%]) and weight loss of at least 3% of initial body weight

New England Journal of Medicine, 389 (24), 22212232

Additionally, previous weight loss attempts and metabolic adaptation (where your body becomes more efficient at conserving energy) may influence initial response rates

Since Semaglutide or Tirzepatide medications regulate insulin levels and suppress appetite, consuming high-sugar foods can also interfere with the medications effectiveness in managing weight

Riddle, M