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doi:10.1016/j.nutres.2015.07.005

GLP-1 and GIP receptors are expressed in regions including the hypothalamus, hindbrain, and area postrema, and tirzepatide is used as a tool compound to probe how dual receptor engagement modulates neuronal firing, appetite-related gene expression, and neuroinflammation markers in cell and organoid systems

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A 2011 review in the European Journal of Pharmacology examined ALA's effects on drug-metabolizing enzymes and concluded that therapeutic oral doses do not produce clinically relevant CYP inhibition [1]