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Our previous research demonstrated that U0126 can inhibit the ERK pathway by reversing the induced levels of pERK1/2 in PFOS-treated RTCs 3

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Senescent cells create a pro-inflammatory and pro-fibrotic milieu by releasing Senescence-Associated Secretory Phenotype (SASP) [28]

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Its probable that DOX eventually reduces OGCs capacity to produce and release E2 by destabilizing mitochondria, the site of steroidogenesis 58,93

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