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As people get older, glutathione not only becomes more depleted due to external stressors, but the bodys ability to rebuild the molecule from its components also slows down

Notably, in the db/db- and the HG-treated SV40-MES-13 cells, the protective effect of astragaloside I on drug-induced renal fibrosis mediated by the Klotho/TGF-1/Smad2/3 pathway can be offset by the ITSA-1 (a HDAC3 agonist) (Zhang X

Lancet 399:14121428

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Sirt5 attenuates cisplatin-induced acute kidney injury through regulation of Nrf2/HO-1 and Bcl-2

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