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These findings indicate that tirzepatide provides superior glycemic control without increasing the risk of hypoglycemia compared to insulin degludec

**Patients without diabetes and with BMI 30, or BMI 27 plus a weight-related condition, lost an average of 20% of their body weight by 1 year in a 72-week trial studying the highest maintenance dose of Zepbound (15 mg), when paired with diet and exercise changes (compared to 3% with diet and exercise alone)

Dankers M, Nelissen-Vrancken MHJMG, Hart BH, Lambooij AC, van Dijk L, Mantel-Teeuwisse AK (2021) Alignment between outcomes and minimal clinically important differences in the Dutch type 2 diabetes mellitus guideline and healthcare professionals preferences

Early guidance helps prevent complications

Building and preserving muscle through resistance training maintains structural volume beneath the skin, which is the most effective exercise-based strategy for reducing loose skin during significant weight loss