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Instead of increasing every four weeks, extending each dose level to six or eight weeks allows the body more time to adapt while the pyridoxine handles the acute nausea component

No side effects, will definitely keep using

(2005b) Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine

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Research shows this reduces the oxygen cost of submaximal exercise by 35% meaning you sustain pace with less perceived effort