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While KRAS and BRAF mutations are certainly two of the most frequently mutated oncogenes in human cancer, they are not the only mutations known to affect glucose metabolism and sensitivity towards ascorbate therapy

The former might affect the latter, no matter the form it was taken in

Funding This work was supported by the Taishan Scholars Program of Shandong Province (tsqn201909141), Shandong Provincial Youth Science and Technology Talents Support Plan (ZR2020YQ56), the National Natural Science Foundation of China (81502736,82073441, 81874244)

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NAC is also a precursor to the antioxidant glutathione

Things like chronic stress, lack of sleep, and a diet high in processed foods can all contribute to this systemic issue