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338 Ferroptosis in autoimmune diseases Autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and myasthenia gravis (MG), are caused by disorders in autoimmune tolerance and the bodys immune response to the self-antigen

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Since mobile phase containing 0.1% OPA has a higher pH than the pKa of the NAC carboxylic group and placebo components, there are insufficient protons (H + ) in solution, and NAC dissociates into its conjugate base and become ionized, resulting in reduced retention, on RP-HPLC

doi: 10.1016/j.autrev.2019.05.001