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Since these medications are not primarily processed by the kidneys, standard dosing schedules are generally appropriate for most CKD stages

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First, GIPR + neurons in the rat hindbrain are located primarily in both inhibitory and excitatory neurons in addition to some expression in oligodendrocytes (69, 87, 88), while GLP-1R is primarily expressed in excitatory neurons

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Amphetamines are exceptionally wake-promoting, and at high doses also reduce cataplexy in narcoleptic patients, an effect best explained by its action on adrenergic and serotoninergic synapses