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Challenges Due to its well-established role in neural tube development, folic acid supplementation is recommended in clinical guidelines (US Preventive Services Task Force, American College of Obstetricians and Gynecologists, American Academy of Family Physicians, American Academy of Pediatrics, and the Center for Disease Control and Prevention) for those who are planning to or could become pregnant (Force et al., 2023)

J., and Mulder G

Oxidative stress and the use of antioxidants in diabetes: Linking basic science to clinical practice

Ding JH, Jin Z, Yang XX, Lou J, Shan WX, Hu YX, et al

Low Levels of Serum Total Vitamin B12 Are Associated with Worse Metabolic Phenotype

While some people report positive results in skin lightening and antioxidant effects, its long-term safety remains a subject of debate