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While a trend toward increased survival probability was observed in animals treated with either compound or their combination, the effect was not statistically significant ( Figure 9B )

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By inhibiting the NNMT enzyme, it prevents the consumption of nicotinamide, allowing it to be recycled back into NAD+ more efficiently

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Periarticular injection (near but not into the joint) near the shoulder injury site may produce faster localized effects than distant subcutaneous injection