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The experiments employed RAMP1 knockout (KO), RAMP3 KO, and RAMP1/3 double KO mice on a 129S2/SvEv genetic background
The pharmacological opposition makes the combination less predictable
The foundational patent work by Harding et al
Many protocols combine routes, using systemic delivery for immune modulation and topical delivery for direct plaque treatment
Initially, there was significant vascularity, as well as penetrating capillaries, mild edema, infiltration of inflammatory cells, and prominent proliferation of fibroblasts, with the synthesis of the reticulin and collagen fibers of the myotendinous junction
