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On-Treatment Analysis (If Everyone Stayed on Max Dose): CagriSema achieved 22.7% weight loss using trial-product estimand (assumes perfect adherence at max dose)

8.4 Psychological and behavioural moderators of eating-experience response Psychological and behavioural factors may be important moderators of eating-experience responses during GLP-1RA treatment and may help explain why changes in appetite, food reward, and food motivation are not uniform across individuals

Technical Bridging Studies Transitioning from an IV vial to an SC injection device usually involves a change of the formulation to one with a higher API concentration to account for the lower bioavailability and limited volume of SC delivery

Wang, N., et al

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