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10.1155/2019/5080843 76 SuY.ZhaoB.ZhouL.ZhangZ.ShenY.LvH.et al (2020)

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It's possible that lower doses of each medication might be sufficient when used together, potentially mitigating some of the side effects while maintaining efficacy

"A novel single nucleotide polymorphism in the 3' untranslated region of human glutathione peroxidase 4 influences lipoxygenase metabolism"

People with diabetes have slightly weaker reactions (1014%), which is probably because their metabolisms are different