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Hormonal variables are relevant to BPC-157 outcomes in women primarily in the context of perimenopause and menopause, where declining estrogen affects collagen synthesis rates and tissue healing capacity

doi: 10.1038/s41380-022-01561-3 302 SadickJ

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The most common causes include metabolic adaptation to weight loss, a dose that no longer matches your needs, gradual dietary drift, loss of lean muscle mass, or an underlying medical factor thats emerged during treatment