GLP-1 receptors are expressed throughout reward-related brain regions: the ventral tegmental area, nucleus accumbens, and lateral septum
Ozempic (semaglutide) shows huge reductions in high-risk heavy drinking, in first-ever clinical trial Powerful findings in Christian Hendershot's RCT w/ 48 non-treatment seekers and relatively low doses of semaglutide
By analysing the administration route, cannabinoids used and formulations, a summative meta-analysis of cannabinoids for pain control has revealed that THC/CBD and THC, administered via the oromucosal route, represent the best score for neuropathic and cancer pains, while THC via the oral route had the best score for cancer pain, standardised dried cannabis via the inhalation route was best for neuropathic pain, and cannabis extract via the oral route was best for nociceptive pain
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The honest summary: Retatrutide probably does produce modestly greater weight loss than tirzepatide at maximum doses, potentially in the range of 36 percentage points of body weight
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