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Combinatorial treatment strategies targeting the gut-brain interplay represent a paradigm shift in managing psychiatric comorbidities in systemic disorders

Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55

doi: 10.1371/journal.pone.0231136 389 NguyenTStainesDJohnstonSMarshall-GradisnikS

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The combination produces a sustained, physiologically timed increase in growth hormone typically administered at night to align with the natural GH pulse during sleep