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When ZO-1 expression is suppressed by inflammatory mediators, the tight junction complex disassembles and barrier permeability increases

As the WL achieved with the novel obesity pharmacotherapies approaches that of bariatric surgery, we will need to assess whether long-term complications observed after bariatric surgery such as increased risk of osteoporosis, fractures, macro- and micronutrient deficiencies as well as self-harm behaviours will also be present with pharmacotherapy [112, 113]

Belichenko PV, Oldfors A, Hagberg B, Dahlstrm A

Specific actionable recommendations emerge from this synthesis: 1

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