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Temporary infections, injuries, autoimmune activity, and intense exercise can increase hs-CRP, so an unexpected elevation may need to be repeated

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It has been speculated that extracellular GS may play a role in the production of poly-L-glutamine-glutamate [25], a polymer found only in pathogenic mycobacterial cell walls, and/or that extracellular GS activity may modulate phagosome pH and thereby prevent phagasome-lysosome fusion [23, 24]