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Research has indicated that the AMPK-PGC-1-Nrf-TFAM axis and the AMPK-SIRT1-PGC-1-Nrf-TFAM axis are two major pathways that regulate mitochondrial biogenesis

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Changes in metabolite and protein expression are now well-correlated with COVID-19 severity, and this approach may facilitate the identification of diagnostic and prognostic markers of disease, yield mechanistic insight and reveal potential therapeutic targets

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