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Challenges, direction for further research, and concluding remarks Since the term eryptosis was coined in 2005 by a group of researchers from the University of Tbingen (Germany) led by Florian Lang [24], a steady and continuous stream of novel papers focusing on eryptosis has been observed

In human tumors, changes in ferritin expression in tumor stem cells have been associated with poor prognosis

Diabetes has reached epidemic proportions globally, with an estimated 537 million adults affected in 2021

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when glucose levels are low, high uptake of cystine by lung cancer cells via the Nrf2/SLC7A11 axis stimulates the accumulation of intracellular disulfide bonds and depletion of NADPH

Whether that change points toward sustainability or simply toward a different set of problems depends on the choices we make in the next few years