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Dihydroorotate dehydrogenase (DHODH), the rate-limiting enzyme in the pyrimidine de novo synthesis pathway, works alongside GPX4 to inhibit mitochondrial lipid peroxidation
this reduces the enzymatic activity of MTHFR by approximately 35% per T allele , resulting in inefficient production of methylfolate ( Figures 3 and 4)
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Because the therapy is individualized, adjustments can be made for patients with varying tolerances or therapeutic goals
We tested the modified Dihexa against 200 M neomycin and observed no protection, suggesting that the current form of Dihexa has a high specificity for providing protection, likely via its specific interaction with native HGF (Figure 7)