Menopause can also be induced by therapies that are toxic to the ovaries, such as radiation therapy and some chemotherapies, or by treatment with anti-estrogenic drugs, such as those used to treat endometriosis or breast cancer
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[1] [2] The vitamin's water-soluble nature means that excess amounts are typically excreted through urine rather than accumulating in the body to toxic levels
Now, many of these inducers will only reduce ethinyl estradiol/progesterone by 10%20%, but the risk is nontrivial and the science inexact, so double protection is a wise strategy here
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