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Altering peptides at the amino-acid level While the strategies for optimisation of small molecules are well established, such as adjusting lipophilicity, installation of (bio)isosteres and using prodrugs, similar strategies for use in peptides are far less developed

These changes, or reactions, can vary in type and severity

doi: 10.1177/1358863X08095154 98

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It will absorb naturally within minutes and leave no residue