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In practice with GHK-Cu: The copper dose delivered via typical topical or therapeutic administration is modest Short-term use has not been prominently associated with clinically significant zinc depletion Long-term or high-dose use warrants monitoring in patients where zinc balance is clinically important Patients with known zinc deficiency or on zinc-replacement should be monitored more closely A reasonable clinical approach: monitor copper and zinc status in patients on chronic GHK-Cu, particularly in symptomatic or long-duration protocols
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The 5-year survival rate is 51%, and the prognosis seems to be closely related to radical surgery (10-year survival: 80% versus 14%, respectively, for patients who had radical or incomplete surgery) [1,6,14,76]
The tight coupling and positive correlation between increased oxidative stress with cytokine levels universally found in numerous previous model systems ranging from cell culture to animals and humans was absent in Rlip knockout mice
