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But how soon does one have to anticipate the first signs of change

We did not estimate a treatment-policy (all-exposed/intention-to-treat-like) effect, as this represents a different estimand and would require additional prespecified analytic assumptions to appropriately handle treatment modification and its potentially non-random occurrence in routine care

I also think people with a history of pancreatitis should be excluded, like non negotiable

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Thus far, the binding poses of two full-length peptide-bound, active GLP-1R structures 3,4 and an active-like structure with a truncated peptide agonist (peptide 5) 12 have been detailed, as well as variable ligand-dependent ECD receptor conformations