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Figure 3 Anti-hyperglycemic medications Therapeutic strategies to improve glycemic control had changed remarkably 12 months after the start of the study in both no/low CKD risk and CKD patients ( Supplementary Figure 1 )

A perfectly chosen site, used repeatedly in the same spot, can become less effective than a rotated thigh site

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The concentration changes proportionally

Importantly, patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2) should not use semaglutide, as noted in the boxed warning