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GLP-1, or Glucagon-Like Peptide-1, is a hormone that plays a critical role in regulating blood sugar levels, appetite, and overall metabolism

NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes

eNOS expression and NO formation also result from receptor-mediated stimulation of the IRS/PI3K/Akt/eNOS insulin signalling pathway

More than 50 genes have been linked to ALS, with the most common being C9ORF72, which causes up to 50% of inherited cases and 510% of sporadic ones

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Identify a biological target of interest and a "bait" molecule that binds that target