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Discussion ILDs comprise a group of lung disorders characterized by various levels of inflammation and fibrosis

The general rule in dermal pharmacology is that molecules above 500 daltons penetrate the intact stratum corneum poorly (the "500-dalton rule" described by Bos and Meinardi in 2000, Experimental Dermatology )

Author contributions DP and GM contributed to conception and design of the study

Compared with the CON group, 104 metabolites were significantly upregulated and 89 metabolites were significantly downregulated in the WKY group (Fig

It is considered safe with no allergic reactions or side effects, but caution is advised for patients with liver or kidney disorders

Realistic expectations include progressive weight loss over a 12-20 week initial period, with the most significant changes becoming apparent after dose escalation is complete